#IDFridays Week 24: Anthrax

This highly contagious disease has been used as a biological weapon

Name
Anthrax

Transmission

  • A severe infectious disease caused by Bacillus anthracis bacteria
  • The bacteria mainly affect wild and domestic plant-eating animals though other types of animals can also contract it
    • Animals become infected when they ingest bacterial spores in contaminated soil, plants, or water (the bacteria can live in the environment for decades)
  • People get sick when the infectious bacterial spores enter the body (often through contact with infected animals or contaminated animal products) but there are three main types of transmission:
    • Cutaneous: Skin injuries (cuts, scrapes) that allow the bacterial spores to penetrate
    • Pulmonary: Breathing in bacterial spores
    • Gastrointestinal: Eating/drinking contaminated food and water
  • Person-to-person transmission is rare, but possible with infection via skin injuries
  • When the spores enter the body they multiply, spread, produce poisons, and cause severe illness

Geography
Worldwide, especially central and South America, sub-Saharan Africa, central and southwestern Asia, southern and eastern Europe, and the Caribbean

Incubation Period

The incubation period varies from 1 day to 60 days depending on the circumstances, for example:

  • When contracted via skin injuries: 1 day
  • When contracted via breathing in bacterial spores: 1-7 days

Signs and Symptoms

Symptoms depend on the type of infection and can appear 1 day to more than 2 months after active infection

  • Cutaneous anthrax
    • A swollen sore (often on the face, neck, arms, or hands)
    • A skin ulcer (often with a black center)
    • Itchy blisters or bumps
  • Pulmonary anthrax
    • Fever
    • Chills
    • Nausea
    • Vomiting
    • Headache
    • Shortness of breath
    • Sweats
    • Extreme fatigue
    • Body aches
    • Stomach pains
    • Chest Discomfort
    • Confusion or dizziness
    • Cough
  • Gastrointestinal anthrax
    • Fainting
    • Fever
    • Hoarseness
    • Swelling of neck or neck glands
    • Diarrhea (with blood)
    • Sore throat
    • Chills
    • Painful swallowing
    • Bloody vomiting
    • Headache
    • Stomach Pain
    • Swollen abdomen
    • Red face
    • Red eyes
    • Nausea

Diagnosis

  • Chest X-rays
  • CT scans
  • Laboratory testing of blood, spinal fluid, skin secretions, and respiratory secretions

Treatment

  • Antibiotics and antitoxins
  • For severe cases requiring hospitalization, draining fluids and using a ventilator machine to support breathing may be part of the treatment

Prognosis

  • Cutaneous anthrax: 20% of people die
  • Pulmonary anthrax: very severe, 85-90% of people die
  • Gastrointestinal anthrax: 25- 50% of people die

Prevention: What Can You Do?

  • There is a vaccine but it has not been properly tested in humans so is often not used
  • If you know you have been exposed to the bacterial spores, antibiotics can prevent a full infection from developing

Anthrax In the News

Sources:
http://www.cdc.gov/anthrax/
http://www.who.int/topics/anthrax/en/

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