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#IDFridays Week 19: Madura Foot

Very little is known about this disease which destroys skin, flesh, and bones

Name
Madura foot (also known as mycetoma)

  • The disease was first reported in the mid-19th century in the Indian town of Madura, which is where it gets its name

Transmission

  • A chronic, progressively destructive disease affecting the foot but can also affect other body parts including skin, flesh, and bones
  • Infection begins when fungi or ‎bacteria enter the body through an injury such as a thorn prick
    • Scientists have discovered 7 types of bacteria and 18 types of fungus that can cause Madura foot
  • It cannot be transmitted from person-to-person
  • Commonly affects:
    • Poor people in rural areas
    • Young male adults between 20 and 40 years
    • Manual workers (labourers, herdsmen, etc.)

Geography

The organisms that cause Madura foot can be found worldwide, but there is a ‘Mycetoma/Madura foot belt’ consisting of the following countries:

  • Venezuela, Chad, Ethiopia, India, Mauritania, Mexico, Senegal, Somalia, Sudan and Yemen

Incubation Period
Madura foot is a neglected tropical disease (NTD) and as such, there is little data on the incubation period

Signs and Symptoms

  • Painless masses on feet and other body parts
    • Most commonly the extremities, back, and gluteal regions
    • Discharge ‎containing grains coming from the masses
  • Can spread to the bone resulting in ‎destruction, ‎deformity and loss of function, which can lead to death
  • If untreated, a secondary bacterial infection can occur, leading to:
    • Pain
    • Disability
    • Septicemia (fatal infection/blood poisioning involving the whole body)

Diagnosis

  • There are no simple diagnostic tests
  • Biopsies of the infected tissue and grains in the discharge are the most common ways to identify the disease
  • DNA sequencing is also possible

Treatment

  • There is no specific treatment for Madura foot as treatment depends on the cause and the affected areas
  • For bacterial infections, treatment usually consists of a combination of antibiotics used over a long period of time
  • For fungal infections, treatment can be a combination of surgery or amputation and antifungal drugs

Prognosis

  • Because Madura foot progresses slowly and is painless, many patients seek medical advice when it is too late and amputation is the only available treatment
  • Early detection and treatment help reduce morbidity and improve outcomes

Prevention: What Can You Do?

  • Preventing the infection is difficult as this is a neglected tropical disease (NTD)
  • When visiting affected areas and endemic countries, do not walk barefoot

Madura Foot In the News

Sources:
http://www.who.int/buruli/mycetoma/en/
http://www.globalhealthnow.org/mycetoma-untold-story-2015.html

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