#IDFridays Week 16: Diphtheria

This bacteria produces a poison that can spread around the body

Name
Diphtheria

Transmission

  • An infection caused by the Corynebacterium diphtheriae bacteria
  • People become infected through direct physical contact with an infected person:
    • Inhaling respiratory droplets from the infected person coughing or sneezing
    • Touching open sores/skin lesions of an infected person (rare)

Geography
Worldwide but more common in tropical climates

Incubation Period
1– 10 days after infection

Signs and Symptoms

  • Fever
  • Chills
  • Headache
  • Thick covering on back of throat
  • Sore throat
  • Nasal discharge
  • Cough
  • Difficulty swallowing
  • Difficulty breathing
  • Swollen glands in neck
  • Pain, redness, swelling and ulcers on the skin (cutaneous diptheria)
  • Paralysis
  • Heart failure
  • Sepsis

Diagnosis

  • Laboratory testing of tissue samples and throat cultures

Treatment

  • An antitoxin can stop the poison produced by the bacteria from damaging the body
  • Antibiotics can kill the bacteria
    • Patients are usually kept in isolation until 48 hours after starting antibiotics so they are no longer contagious

Prognosis

  • Fatal in 5 – 10% of cases, with a higher mortality rate in young children
    • Was once a major cause of illness and death among children worldwide

Prevention: What Can You Do?

  • Ensure you get the vaccine to protect yourself
    • The vaccine is usually combined with vaccines for tetanus and whooping cough (pertussis)

Diphtheria In the News

Sources:
http://www.cdc.gov/diphtheria/
http://www.who.int/immunization/diseases/diphtheria/en/

 

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